CLINICAL SUBTYPES OF PARKINSON’S DISEASE

Abstract

There is increasing evidence that Parkinson disease (PD) is heterogeneous in its epidemiology, clinical presentation and prognosis. Defining subtypes of PD is needed to better understand underlying mechanisms, predict disease course, and eventually design more efficient personalized management strategies. A number of studies using empirical or data-driven approaches have proposed and defined subtypes of PD based on clinical features that tend to cluster together. In this paper, we review what subtypes have been identified in PD so far and we also refer to attempts that aim to find corresponding PD subtypes from both classifications.