A YOUNG FEMALE PATIENT WITH MOG ANTIBODY-ASSOCIATED DISEASE AND CLINICAL AND RADIOLOGICAL DISEASE PROGRESSION: A CASE REPORT

Abstract

Introduction: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an immune-mediated demyelinating disease of the central nervous system. The development of newer cell-based assays for the detection of MOG antibodies further elucidates the highly heterogenous MOGAD phenotype. Furthermore, disease progression independent of relapses is uncommon among MOGAD patients compared to multiple sclerosis (MS) patients.

Case report: Here we present a case of a female patient with MOGAD manifesting recurrent episodes of seizures, neurological deficits, and evidence of clinical and imaging deterioration regardless of disease relapses.

Conclusion: Our case comes to add to the growing clinical phenotype of the disease as well as to highlight the need to further investigate the incidence of relapse-free progression of the disease.