ANTIOXIDANT VITAMINS C AND E IN MIGRAINE: A NARRATIVE REVIEW

Abstract

Background: Although the pathophysiology of migraine is still unclear, oxidative stress is implicated as part of the mechanism, while several studies have reported a redox imbalance in migraine patients.

Objective: This narrative review examines the role of the antioxidant vitamins C and E in the treatment of migraine.

Results: Observational studies suggest that increased—but balanced—consumption of dietary antioxidants, including vitamins C and E, resulted in a lower risk of migraine and a lower frequency and severity of migraine attacks, especially in women of reproductive age. In addition, other observational studies and one randomized trial provide evidence that vitamin C supplementation (when taken alone or concomitantly with other antioxidants) may be beneficial for migraine outcomes in terms of frequency, duration, and intensity. However, a cross-sectional study from Taiwan reported an increase in migraine attacks in women taking vitamin C supplements. As for vitamin E, its antioxidant and anti-inflammatory properties may help control some migraine symptoms, particularly those associated with menstrual migraine.

Conclusions: Overall, the current evidence offers some hope for the use of vitamins C and E in the treatment of migraine. Future research and randomized controlled trials may help identifying dosing and specific patient groups who might benefit from vitamin C and E supplementation.