Genetics of benign partial epilepsy with centro-temporal spikes (Rolandic epilepsy)

Abstract

nign Partial Epilepsy with Centro temporal Spikes (Rolandic epilepsy) is considered to be the most common childhood epileptic syndrome. Most epileptic syndromes have a complex trait of inheritance. In recent
years, different mutations in genes that control the excitability of neurons have been described. Recent reports on the involvement of the BDNF and ELP4 genes with possible roles in neural cell differentiation and
migration have provided first insights into the complex molecular bases of childhood focal epilepsies. However, in the most common idiopathic benign childhood epilepsies, major breakthroughs are still awaited.